After making a lot of efforts to conceive naturally, you (couples of the opposite sex) decide to visit the best ICSI clinic in Bangalore or your locality. After knowing your conception issues and medical history during the interaction, a respective doctor conducts physical examinations and recommends a few tests to assess your fertility. When your test reports reveal something abnormal that is not addressable through IVF alone, the doctor advises ICSI with your IVF treatment. 

What is ICSI?

A single sperm is injected directly into the cytoplasm of a human egg during the advanced in vitro fertilisation (IVF) technique known as intracytoplasmic sperm injection, or ICSI. Couples who struggle with severe male infertility or who have previously experienced fertilisation failure with conventional insemination benefit from this treatment. Some fertility centres routinely perform ICSI before each IVF cycle, while others typically reserve the procedure for couples who have serious infertility issues.

Why do couples need ICSI?

If a couple is dealing with any of the following difficulties:.

  • Low sperm counts, also known as oligospermia
  • Low sperm motility is a condition called asthenozoospermia
  • Sperm that have not developed properly are known as teratozoospermia
  • TESE, or testicular sperm extraction, is a method of sperm recovery
  • retrograde ejaculation
  • Although frozen sperm is being used, it doesn’t seem to be functioning
  • The procedure known as PGD, or preimplantation genetic diagnosis, is used
  • Mysterious infertility
  • Cryopreserved oocyte fertilisation
  • The female partner is older than the male partner
  • Low oocyte yield

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What steps are involved in receiving ICSI treatment?

  • Oocytes from female donors are removed using the transvaginal oocyte retrieval procedure.
  • Additionally, the partner’s sperm is obtained on the same day as the egg collection.
  • A holding pipette gently suctions through a microinjector to stabilise the oocyte or egg.
  • A single sperm is carefully picked up after the tail has been cut off with a hollow, sensitive, and sharp needle, immobilising it.
  • The sperm is carefully removed after being carefully injected into the cytoplasm with the aid of a needle.
  • Polar bodies are positioned at 12 or 6 o’clock to stabilise the oocyte.
  • The egg is placed in cell culture, examined the following day for signs of fertilisation, and then the growth of the embryo is tracked over the following days.
  • It is inserted into the woman’s uterus after the embryo has grown for 3 to 5 days. After 14 days, a blood test is performed to confirm pregnancy.

How effective is ICSI in treating infertility?

The current fertilisation rate in the IVF laboratory, which ranges from 80 to 85 percent, sheds light on the ICSI success rate. Male infertility couples who use ICSI have seen fertilisation rates of between 70 and 80 percent for all injected eggs, which is comparable to fertilisation using regular sperm. The pregnancy rates achieved by ICSI are comparable to those achieved by IVF in couples without male factor infertility.


ICSI may cause birth malformations, contrary to the belief of some medical professionals, but it’s also possible that it does so because parents who receive the procedure run the risk of having abnormalities. A person should consult their doctor before undergoing ICSI treatment so that they can learn about the risks and side effects.